Role of IGF1 in primary ovarian cancer – a study of the OVCAD European Consortium
I Rohr, R Zeilinger, M Heinrich, R Richter, N Concin, I Vergote, S Mahner, T Van Gorp, F Trillsch, D Cacsire-Tong, R Chekerov, J Sehouli, EI Braicu · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: IGF1 (insulin growth factor 1) is a hormone crucially involved in the physiology of cellular proliferation. Moreover, deregulation of IGF1 was shown to be relevant in the carcinogenesis of various tumor entities including breast cancer. However, the impact in the pathophysiology of ovarian cancer is unclear. Therefore we investigate the predictive and prognostic role of IGF1 circulatory levels in a collective of 275 primary epithelial ovarian cancer (EOC) patients. Methods: In the FP6 European Multicentric Project "OVCAD", 275 consecutive patients with primary EOC were enrolled. Patients were eligi…
