ALDH1+ cancer stem cells in epithelial ovarian cancer are associated with chemoresistance and poor survival
K Kübler, MD Keyver-Paik, M Debald, B Rostamzadeh, T Thiesler, TH Ayub, L Schröder, L Otten, A Abramian, C Kaiser, G Kristiansen, W Kuhn · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Although epithelial ovarian cancer (EOC) is chemosensitive, the frequent occurrence of drug resistance in the course of the disease persists to be a problem and is a key factor in the high mortality rate. Cancer stem cells (CSCs) are defined as malignant cells with a stem cell phenotype. They have the exclusive ability to self-renew and maintain the tumor. CSCs have also been suggested to contribute to chemoresistance. Thus, identification and characterization of CSCs might fuel the development of CSC-targeted therapeutics and improve survival rates. Methods: The study population consisted of a ret…
