The effects of phytoestrogen extracts isolated from elder flower on hormone production and proliferation of trophoblast tumour and breast cancer cell lines
L Schröder, B Piechulla, M Chorbak, C Kuhn, S Schulze, S Abarzua, T Weißenbacher, U Jescke · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Lignans and flavonoids have a controversial effect on hormone-dependent tumours. Herein we investigated the effect of the elderflower extracts (EFE) on hormone production and proliferation of trophoblast tumour cells Jeg 3 and BeWo, as well as MCF 7 breast cancer cells. Methods: The EFE was prepared and analyzed by mass spectrometry. MCF7, Jeg3 and BeWo cells were incubated with various concentrations of EFE. Untreated cells served as controls. Supernatants were tested for estradiol production with an ELISA method. Furthermore, the effect of the EFE on ER-α/ER-β/PR expression was assessed by immunocy…
