An in vitro system for the identification of DILI related signaling?

Chemicals present in consumer products or drugs might pose a potential hazard to humans. The conversion of these chemicals into reactive intermediates by cellular metabolism may lead to the production of reactive oxygen species (ROS) and the formation of DNA or protein adducts. At low, non-toxic doses, Drug-Induced Liver Injury (DILI) can occur in rare incidence. It involves the immune system and often results in the withdrawal of drugs from the market once it becomes apparent. Here we investigated the toxic effects of the DILI-inducing drug, ketoconazole, on hepatocytes in vitro. Ketoconazole, a drug used to tr…