Endoglin Knockdown inhibits Proliferation and NO Production in murine Sinusoidal Endothelial Cells in vitro

Introduction: Endoglin (ENG) is a 180 kDA homodimeric membrane protein which acts as an auxiliary TGF-β Receptor modulating TGF-β downstream signalling. It plays an important role in various cellular processes like proliferation and differentiation. ENG is also involved in VEGF/eNOS signalling and nitric oxide (NO) production thereby fine-tuning angiogenetic processes. However, the interplay between ENG, eNOS and VEGF has still not been clarified and is an object of current research. Aim: Here we investigate the influence of ENG on NO production and VEGF-induced proliferation in primary murine liver sinusoidal e…