MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3
O Böhmer, C Ehlting, MJ Hahnel, M Thomas, UM Zanger, M Gaestel, WT Knoefel, J Schulte am Esch, D Häussinger, JG Bode · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Oncostatin M (OSM) is expressed in the context of several inflammatory diseases and plays a role in liver regeneration after liver injury. It is mainly secreted by activated T lymphocytes, monocytes and macrophages such as the Kupffer cells of the liver. As a member of the IL-6-type cytokine family it is also involved in the regulation of acute phase protein expression in hepatocytes. Binding of OSM to its cognate receptor complex, activates several signaling cascades. This includes signals mediated via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and those mediated via…
