Targeting TGF-β2 in chronic liver diseases

Abstract: Background and aims: Expression and function of TGF-β2 have not been investigated thoroughly in chronic liver disease (CLD) progression and HCC. Upon providing further evidence that TGF-β2, like TGF-β1 plays a putative role in fibrogenesis, we now aim to selectively target TGF-β2 expression or both, TGF-β2 and TGF-β1 together using antisense oligonucleotides (AONs) for attenuation or even blockage of human liver disease progression. Methods: For our study three CLD mouse models (CCl4, BDL & Mdr2-/-) were investigated representing different types of CLD background. TGF-β2 expression was compared to TGF-…