A novel function of necroptosis in Non-Alcoholic Steatohepatitis
J Gautheron, M Vucur, F Reisinger, A Canbay, F Tacke, C Trautwein, M Heikenwälder, T Luedde · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Non-alcoholic fatty liver disease represents the most common liver disease in Western countries and often progresses to non-alcoholic steatohepatitis (NASH) leading ultimately to liver fibrosis and hepatocellular carcinoma. The occurrence of hepatocyte cell death – so far characterized as hepatocyte apoptosis – represents a fundamental difference between benign steatosis and progressive steatohepatitis. Recently, it was discovered that RIP3-dependent “necroptosis” represents a novel programmed cell-death-pathway activated in chronically inflamed tissues. This novel pathway is counterbalancing the function of Cas…
