A20(TNFAIP3) as modulator of TNFα-induced responses in mouse hepatoma cell lines and primary mouse hepatocytes

Backround/Aims: The tumor necrosis factor-α (TNFα)/NF-kB pathway is known to be involved in several cell responses depending on the nature of its stimulation. In liver, specific macrophage- or endothelial cells-derived TNFα defines very different cellular behaviors in hepatocytes (apoptosis, survival, proliferation). Different in vivo and in vitro models show that TNFα stimulation combined with simultaneous perturbation of NF-kB signalling is leading to apoptosis. Input signals from TNFα require processing from a protein complex system downstream of the TNFα receptor (TNFRI), referred as signalosome. However, mo…