Novel tumor suppressor genes SORBS3 and SH2D4A repress IL-6 signaling in hepatocellular carcinoma

Background: Different inflammatory states, e.g. chronic hepatitis B or C viral infection, have been shown to contribute to the development of hepatocellular carcinoma (HCC). In patients with chronic liver disease the serum levels of interleukin 6 (IL-6) are elevated and increase even more when HCC develops. However, there is still not much known about the regulation of IL-6 signaling during hepatocarcinogenesis. Recently, we applied an integrative genomic and transcriptomic approach which revealed that loss of chromosome 8 p is associated with poor prognosis. In addition, we showed that the two chromosome 8 p ge…