Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development
AM De Ponti, D Schneller, T Pusterla, L Wiechert, T Longerich, S Marhenke, P Schirmacher, A Vogel, E Pikarsky, J Hess, P Angel · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
The Receptor for Advanced Glycation-End products (RAGE) is a multi-ligand receptor, mainly involved in tissue damage and inflammatory disorders. RAGE and its ligands S100A8 and S100A9 have been shown to be overexpressed in tumors, including hepatocellular carcinoma (HCC), enhancing cancer progression and metastasis by still unknown mechanisms. To address the role played by RAGE and S100A8/A9 in HCC onset and development, we took advantage of two mouse models: (i) the multidrug resistance 2 knock-out (Mdr2-/-) mouse and (ii) treatment with the procarcinogen diethylnitrosamine (DEN). The Mdr2-/- mouse shows chroni…
