Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
A Carambia, B Freund, D Schwinge, OT Bruns, SC Salmen, H Ittrich, R Reimer, M Heine, S Huber, C Waurisch, A Eychmüller, DC Wraith, T Korn, P Nielsen, H Weller, C Schramm, S Lüth, AW Lohse, J Heeren, J Herkel · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background/Aims: Previously, we have shown that ectopic expression of a neural autoantigen in the liver induced the generation of autoantigen-specific CD4+ Foxp3+ regulatory T cells (Tregs) that could suppress experimental autoimmune neuroinflammation (Lüth S et al., J Clin Invest. 2008). Moreover, we identified liver sinusoidal endothelial cells (LSECs) as the major antigen-presenting cell type responsible for hepatic Treg induction (Carambia A et al., J Hepatol. 2014). Here we aimed to explore whether targeted delivery of autoantigen-peptides to LSECs could be harnessed for the induction of autoantigen-specifi…
