Allergy protection mediated by Lactococcus lactis G121-stimulated dendritic cells requires endosomal acidification and activation through TLR13

Introduction: Epidemiological studies show that traditional cattle farming environment during fetal development and in early childhood reduces the incidence of allergies later in life. A variety of bacterial strains including Lactococcus lactis G121 have been isolated from cowsheds and proven to be allergy-protective in various mouse models. Up to now, the identity of mediators of the allergy-protective effect of L. lactis G121 is largely lacking. Objectives: Identification of the central mechanisms and receptors by which L. lactis G121 induces an allergy-protective immune response. Material and Methods: Challen…