Removal of Soluble Fms-like Tyrosine Kinase (sFlt-1) by Plasma-Specific Apheresis: A Pilot Study in Women with Severe Preterm Preeclampsia
W Schaarschmidt, R Thadhani, H Hagmann, B Roth, T Kisner, SA Karumanchi, J Wenger, KJ Lucchesi, T Hector, T Lindner, A Fridman, U Thome, A Kribs, M Danner, P Mallmann, H Stepan, T Benzing · Geburtshilfe und Frauenheilkunde · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: Soluble Fms-like tyrosine kinase-1 (sFlt-1) is a potential therapeutic target in preeclampsia. We evaluated the safety and efficacy of treating women with very preterm preeclampsia using a plasma-specific dextran sulfate (PSDS) column to remove circulating sFlt-1. Methods: This was an open study of up to three extra-corporeal PSDS-apheresis treatments in 10 women with very preterm preeclampsia to determine the extent of sFlt-1 and proteinuria reduction, and its safety for mother and fetus. Results: Six patients with very preterm preeclampsia (mean gestational age 29 + 2 weeks) underwent one PSDS-aphe…
