CareLit Fachartikel
Golgi-associated protein sorting influences lipid droplet and lipoprotein formation
D Hesse, A Jaschke, M Lagerpusch, B Chung, A Tailleux, B Staels, A Schürmann · Diabetologie und Stoffwechsel · 2015 · Heft 04
Dokument
1114690
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: An adequate lipid homeostasis involving storage and distribution of lipids is crucial as disturbances contribute to fatty liver disease, type 2 diabetes and atherosclerosis. Dietary lipids are absorbed by the intestine and packed in chylomicrons (CM) for distribution. In the liver, lipids are either stored in cytoplasmic lipid droplets (LD) or secreted as very low density lipoproteins (VLDL). Generation of LD and VLDL/CM is initiated in the endoplasmic reticulum, followed by lipidation at the Golgi. Our aim was to clarify the role of Golgi-associated proteins in LD and VLDL/CM formation. ADP-ribosyla…
Schlagworte
Caco-2 Cells
After
ADP-Ribosylation
Atherosclerosis
Chylomicrons
Diabetologie und Stoffwechsel
