Mechanisms of IKK/NF-κB dependent diabetes development

As a key regulator of inflammatory processes IKK/NF-κB signaling is present and activated in all cell types involved in diabetes development. However, a detailed understanding of the causal relationship between cell-type-specific NF-κB activation and onset and progression of type 1 diabetes needs further investigation. To address this issue, two complementary mouse models (gain- and loss-of-function) for IKK/NF-κB signaling were generated. Both mouse models are based on the conditional expression of mutant IKK2 alleles (constitutive active (IKK2-CA) and dominant negative (IKK2-DN)) via the tetracycline-regulated…