C-terminal agrin fragment (CAF) – a potential new biomarker for prediction of diabetic kidney disease
M Roos, S Kopf, S Hettwer, D Oikonomou, M von Eynatten, U Heemann, D Steubl, PP Nawroth, A Bierhaus, P Humpert · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: Serum creatinine and albuminuria fail in terms of sensitivity and specifity as prognostic biomarkers for monitoring renal damage and the progression to diabetic nephropathy. C-terminal agrin fragment (CAF, 22 kDa) is a promising new biomarker for kidney function. This study evaluated the usefulness of CAF as a biomarker for diabetic nephropathy in type 2 diabetes patients. Methods: CAF serum and urine levels were assessed by ELISA in a cross-sectional setting in 138 patients with type 2 diabetes with diabetic nephropathy and 26 healthy controls. Associations of CAF with renal function and metabolic m…
