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Identification of novel susceptibility genes for diabetes- and obesity-related traits in a backcross of obese NZO with lean C3 H mice

T Schallschmidt, S Osthold, Y Schulte, M Damen, T Stermann, A Chadt, H Al-Hasani · Diabetologie und Stoffwechsel · 2015 · Heft 04

Dokument
1114701
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Jahr
2015
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
T Schallschmidt, S Osthold, Y Schulte, M Damen, T Stermann, A Chadt, H Al-Hasani
Ausgabe
Heft 04 / 2015
Seiten
–
Erschienen: 2015-04-29 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0035-1549627

Zusammenfassung

Background and aims: Type 2 diabetes (T2D) in humans is influenced by a combination of hundreds of adipogenic and diabetogenic alleles. In outcross experiments of obese and lean mouse strains, several QTL (Quantitative Trait Loci) for obesity and hyperglycaemia were separated. Mouse models could therefore help to identify several key obesity and diabetes modifier genes. In order to find further disease genes we performed a new crossbreeding approach and subsequent QTL analysis with obese New Zealand Obese (NZO) and lean C3HeB/FeJ mice. Methods: We measured phenotypic traits associated with obesity and T2D in 310…

Schlagworte

Obesity Blood Glucose Chromosomes Population Alleles Blood Diet Diabetologie und Stoffwechsel