Hepatic heat shock proteins in Diabetes and long term diabetic complications

Aims: Diabetes mellitus type 2 (DM 2) and its complications include intracellular accumulation of damaged and misfolded proteins, while protective heat shock proteins (HSP) are repressed. We aim to identify HSP-regulated liver-to-periphery signalling pathways effecting the development and progression of long term diabetic complications. Methods: Livers of DM 2 mice (db/db) were analyzed for expression levels of HSPs. In-vivo reconstitution of HSPs in db/db mice was achieved via hepatocyte-specific adenoviral constructs for Hsp70, DNAJB1 and DNAJA2. Results: In db/db livers, central HSPs were significantly downre…