Serum bile acids in adolescents with type 1 diabetes: a new marker for glycaemic control?
E Zöhrer, M Heckmann, E Fröhlich-Reiterer, H Jasser-Nitsche, G Fauler, H Scharnagl, T Stojakovic, J Jahnel · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: High levels of bile acids (BA) stimulate insulin release and therefore decrease serum glucose levels; vice versa, high glucose levels can upregulate BA synthesis from cholesterol by stimulating the enzyme Cyp7a1. Type 1 diabetes (T1D) leads to hyperglycaemia due to lack of endogenous insulin. We hypothesized that in adolescents with T1D BA levels vary co-ordinately with HbA1c, a long time marker of glycaemic control. Design: Concentrations of glucose, HbA1c, and serum total BA (tBA) were measured in 86 fasted adolescents with T1D (age 11 – 20 years) under insulin therapy. Patients were divided into th…
