Coagulation factor XII mediates fibrotic response to lung injury
M Wygrecka, E Jablonska, I Henneke, T Renne, K Panousis, B McKenzie, D Kosanovic, G Kwapiszewska, MW Nolte, RT Schermuly, KT Preissner, P Markart · Pneumologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Rationale: Idiopathic pulmonary fibrosis (IPF) is the most aggressive and common form of diffuse parenchymal lung diseases. Albeit, disturbance in haemostatic balance was observed in IPF lungs, the role of factor XII (FXII) in the development of pulmonary fibrosis has never been addressed. Methods: FXII expression was examined in the lungs of patients with IPF. The effects of FXII on fibroblast proliferation, differentiation and extracellular matrix production were assessed in vitro. The importance of FXII in experimental pulmonary fibrosis was examined using FXII knockout mice and FXII inhibitors. Results: Incr…
