Event and cost offsets of a partial switch from multiple daily injections to continuous subcutaneous insulin infusion in type 1 diabetes patients in Germany: a four-year simulatio…

Background: Most type 1 diabetes mellitus (T1D) patients administer insulin by multiple daily injections (MDI). However, continuous subcutaneous insulin infusion (CSII) therapy has been shown to improve glycaemic control and health-related quality of life (QoL). Objective: To determine the key medical event and cost offsets, over a 4-year period, generated by introducing CSII for T1D patients currently inadequately controlled on an MDI regimen in Germany. Methods: A decision-analytic model, simulating a switch scenario, was developed. In the base case, all T1D patients receive MDI, while in the switch scenario,…