Effects of vitamin D supplementation on liver stiffness in patients with chronic liver diseases

Introduction: Vitamin D deficiency (VDD) is common in chronic liver diseases (CLD), and and we have demonstrated that unfavorable genetic polymorphisms of genes controlling vitamin D metabolism are associated with increased liver stiffness in CLD patients (Grünhage et al. Hepatology 2012). Our aim now was to analyse CLD patients with respect to vitamin D and liver phenotypes. Patients and methods: Patients were randomly retrieved in our hospital information system and fulfilled the characteristics of at least one of the following three groups: Group 1 consists of CLD patients with VDD (serum concentrations 20 ng…