CareLit Fachartikel

Modification of the CD14 receptor is associated with biliary stricture formation

K Friedrich, M Smit, C Rupp, A Wannhoff, K Weiss, W Stremmel, D Gotthardt · Zeitschrift für Gastroenterologie · 2015 · Heft 08

Dokument
1115111
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
K Friedrich, M Smit, C Rupp, A Wannhoff, K Weiss, W Stremmel, D Gotthardt
Ausgabe
Heft 08 / 2015
Seiten
–
Erschienen: 2015-08-18 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0035-1559097

Zusammenfassung

Introduction: The pathogenesis of intrahepatic biliary stricture formation in patients with primary sclerosing cholangitis (PSC) or after liver transplantation remains elusive. Methods: We genotyped both a long-term prospective PSC and a liver transplantation cohort (Ltx) for the CD14 – 260C>T (rs2569190), IL-6 – 174C>C (rs1800795), and TNFα -238G>A (rs1800629) polymorphisms. Biliary tissue, bile and whole blood were screened for markers of the innate immune system and bacterial infection. Results: In PSC patients, the CD14 – 260C>T genotype was associated with development of dominant bile duct strictures (p= 0.…

Schlagworte

Transplantation Chemokine Cholangitis Blood After Zeitschrift für Gastroenterologie