Panel of MiRNAs -122,-192 and -21 correlate with CK-18 fragment level in serum and hold potential as non-invasive NASH biomarkers

Objectives: Liver biopsies are the current gold standard in NASH diagnosis. Their invasive nature, however, still carries an increased risk for patients' health. For optimal follow-up and treatment of NAFLD patients, development of non-invasive diagnostic tools to differentiate between NAFL and NASH remains crucial. The aim of this study is the evaluation of investigated microRNAs in combination with new targets in order to optimize the discrimination of NASH patients by non-invasive serum biomarkers. Methods: Serum expression of four microRNAs was evaluated in two cohorts consisting of 136 NAFLD patients and 61…