Photochemical Internalisation (PCI) is a novel technology for treatment of cholangiocarcinoma
B Neu, R Sturgess, R Wentrup, J Trojan, S Kasper, A Dechêne, J Schirra, A Hoffmeister, M Dollinger, R Jakobs, A Høgset, J Borgaard · Zeitschrift für Gastroenterologie · 2015 · Heft 08
Bibliografische Angaben
Zusammenfassung
Despite the advancement of new surgical and chemotheraputic treatment options for patients with extrahepatic cholangiocarcinoma (CCA), the prognosis for patients is still poor. PCI is a novel technology which could prove to contribute to the treatment options for this patient group. PCI is a relatively new treatment modality that can enhance the anti-tumor effect of a variety of molecules, including several commonly used cytotoxic drugs. Amphinex (TPCS2a) is a proprietary photosensitizer that is used to induce PCI. It is designed to localise to endosomal membranes and induce endosomal disruption upon light activ…
