A new mouse model of sclerosing cholangitis combining toxic and immune mediated bile duct injury
F Glaser, B Engel, C John, T Krech, A Carambia, J Herkel, AW Lohse, J Heeren, C Schramm, D Schwinge · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Introduction: Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic liver disease leading to fibrosis and obliteration of bile ducts, and eventually to cirrhosis and end stage liver disease. Currently there is no medical treatment with a proven benefit on disease progression. The etiology of PSC is largely unknown, but immune dysregulation and toxic biliary damage are considered to be part of PSC pathogenesis. There is an urgent need for a reliable mouse model, which allows a standardized testing of novel treatment strategies for PSC. We here describe a new mouse model of sclerosing cholangitis, which co…
