Antiapoptotic and antioxidative protein ALR in Cholestatic Liver Diseases – Do bile acids regulate ALR expression via Egr1?

Cholestatic liver diseases result when the excretion of bile acids from the liver is interrupted. It has been shown that inflammation contributes to liver injury during cholestasis and previous studies indicated that bile acids up- regulate early growth response fator-1 (Egr1) through the activation of MAPK signaling pathway. Egr1 is responsible for the development of the inflammation through up-regulation of several pro-inflammatory genes. Augmenter of liver regeneration (ALR) is a hepatotrophic factor with anti- oxidative and anti-apoptotic properties which has been found to be highly expressed in regenerating…