CareLit Fachartikel
Expression of genes and pathways associated with colorectal liver metastases in an orthotopic and syngeneic mouse model
D Bocuk, A Wolff, S König, T Beißbarth, P Krause · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
1115338
CareLit-ID
Jahr
2015
Publikation
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Metadaten
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Zusammenfassung
Background: Colorectal cancer (CRC) is the second most common cause of cancer-related death in men and women. Systemic disease with metastatic spread to distant sites remains a major challenge. The aim of this study was to investigate the molecular requirements necessary during the evolution of CRC cells in the liver environment. Methods: Cells from the CMT-93 cell line (originating from mouse CRC) were cultured in RPMI. For analysis in vivo, one million cells were injected via the portal vein into syngeneic mice livers, leading to the formation of stable metastases within three weeks. RNA of the CMT-93 cells an…
Schlagworte
Liver
Cells
Genes
Expression
Metastases
During
Cmt-93
Analysis
Pathways
Study
Investigate
Necessary
Zeitschrift für Gastroenterologie
