Role of new pathways in liver regeneration after acute and chronic liver damage
K Behnke, PA Lang · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
The liver is a vital organ that performs many biological functions (e.g. synthesis of bile and blood proteins, detoxification, glycogen storage, innate immunity). Interestingly, the liver also has a unique ability to regenerate following the loss of liver mass. Loss of at least 30% of liver mass, leads to synchronized proliferation of mature hepatocytes and rapid restoration of liver mass via compensatory hyperplasia. When a liver has recovered after chronic damage caused by e.g. viral infection the whole complex architecture of the liver must be restored. Hepatic stellate cells (HSCs) are mainly known for their…