Hypothalamic inflammation in humans is not reversed by a profound weight loss and an improved insulin sensitivity due to bariatric surgery
C Kreutzer, S Peters, DM Schulte, K Türk, S Wolff, A Rohr, T Kerby, C Riedel, T van Eimeren, S Schreiber, M Laudes · Diabetologie und Stoffwechsel · 2016 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: Obesity is associated with hypothalamic inflammation (HI) in animal models. While MRI studies in humans also found an increased intensity in the MBH in obese subjects it remains unclear (1) if HI causes neuronal death and (2) if HI reverses during weight loss. Patients and methods: n = 50 obese subjects and n = 50 age- and sex-matched controls where examined. MRI scans including spectroscopy were performed. Also, detailed nutritional questionnaires, serum lipidomics, 16 s rRNA microbiome sequencing data as well as Array-based genotyping data were obtained. n = 10 obese subjects underwent bariatric…
