Improved glycaemic control by chronic interval training in mice

Research Question: Regular exercise training is a common intervention to improve glucose metabolism and insulin sensitivity in type-2 diabetic patients. Recent studies have considered high-intensity training as an efficient alternative to moderate endurance training in humans. We sought to develop a similar interval training protocol that induces exercise-mediated improvements of glycaemia in mice. Methodology: Male C57BL/6J mice were fed a high-fat diet (HFD) with 60% fat from calories after weaning. At week 15, mice were subjected to forced treadmill training for six weeks during their active phase. Each 1-hou…