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Chromosomal aberrations of M0 versus M+ non-WNT/non-SHH medulloblastomas

T Goschzik, E Dörner, V Dreschmann, A von Bueren, BO Juhnke, S Rutkowski, T Pietsch · Klinische Pädiatrie · 2016 · Heft 05

Dokument
1115832
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
T Goschzik, E Dörner, V Dreschmann, A von Bueren, BO Juhnke, S Rutkowski, T Pietsch
Ausgabe
Heft 05 / 2016
Seiten
–
Erschienen: 2016-05-02 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0036-1582507

Zusammenfassung

Introduction: Whole genome analysis of non-WNT/non-SHH medulloblastomas (MB) was performed to compare chromosomal aberrations between MB without metastases (M0) and metastatic MB (M+). Methods: 57 M0 and 79 M+ MB were analyzed by molecular inversion profiling and whole chromosomal aberrations (WCA) were assessed. Results: Chr. 7 gain (M0, 49%; M+, 37%) and chr. X loss (M0, 32%; M+, 22%) were the most frequent WCA in both groups. In both cohorts loss of chr. 11 was associated with favourable outcome (5-year PFS: M0, 100% (n = 13) vs. 71%; M+, 81% (n = 16) vs. 50%). Gain of chr. 7 and loss of chr. 8 were predictiv…

Schlagworte

Chromosomal Aberrations Outcome Non-Wnt Non-Shh 5-Year Medulloblastomas Whole Between Associated Predictive Better Klinische Pädiatrie