Influences in gene expression of transmembrane glycoprotein non-metastatic protein B in breast cancer cells by nuclear macrophage capping protein

Expression of the macrophage capping protein (CapG) is increased in about 30% of breast cancer and correlates with invasion potential of tumor cells. Moreover, nuclear localization of CapG seems to be important to increase the invasion potential. However, its function in the nucleus is unclear. In order to understand CapG's role in the cellular invasion processes its function in transcription should be investigated. The aim of this study was to perform transcriptome analyses to identify CapG-regulated transcripts. CapG knock-down and overexpression was performed in breast cancer cell lines using siRNA and retrov…