Virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension
M Mandorfer, K Kozbial, P Schwabl, C Freissmuth, R Schwarzer, R Stern, D Chromy, AF Stättermayer, T Reiberger, S Beinhardt, W Sieghart, M Trauner, H Hofer, A Ferlitsch, P Ferenci, M Peck-Radosavljevic · Zeitschrift für Gastroenterologie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background & aims: Portal pressure, assessed by hepatic venous pressure gradient (HVPG)-measurement, drives the development of liver-related complications and mortality in patients with advanced liver disease. Since a decrease in HVPG translates into a clinically meaningful benefit, it is considered an acceptable surrogate endpoint for etiologic therapies. We aimed to investigate the effect of viral suppression with interferon (IFN)-free therapies on portal hypertension in patients with paired HVPG-measurements. Methods: Ninety patients with portal hypertension (HVPG≥6 mmHg) who achieved a sustained virologic re…
