Heterogeneity of young patients with new-onset diabetes mellitus
M Heinrich, F Haupt, C Winkler, S Jergens, D Endesfelder, P Becker, N Antl, K Warncke, P Achenbach, AG Ziegler · Diabetologie und Stoffwechsel · 2016 · Heft 06
Bibliografische Angaben
Zusammenfassung
The clinical phenotype of diabetes differs among newly-diagnosed children and adolescents. In this study, we asked whether heterogeneity in immunopathology, reflected by different autoantibody profiles, is associated with clinical phenotypes. 971 patients with new-onset diabetes, aged < 20 years were clustered according to type 1 diabetes-associated autoantibody profiles (IAA, GADA, IA-2A, ZnT8A) and analyzed with respect to clinical phenotype. Patients presented with all possible autoantibody combinations with varying frequencies ranging from 2% (single IA-2A positive) to 30% (four autoantibodies). 62% had thre…
