CareLit Fachartikel

Modeling of TGFβ pathway dynamics in lung cancer cells

D Dvornikov, R Engesser, M Schilling, S Depner, J Timmer, U Klingmüller · Pneumologie · 2016 · Heft 07

Dokument
1115894
CareLit-ID
Jahr
2016
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
D Dvornikov, R Engesser, M Schilling, S Depner, J Timmer, U Klingmüller
Ausgabe
Heft 07 / 2016
Seiten
–
Erschienen: 2016-07-28 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0036-1584627

Zusammenfassung

Rationale: Transforming growth factor-β (TGFβ)-induced effects are different, even opposite, depending on the cellular type and conditions. TGFβ signaling has been widely acknowledged to contribute to cancerogenesis via enhancing tumor cell metastasis. Numerous attempts to target TGFβ pathway to reduce cancer spread proved to be ineffective. Aim: In the current work we aim to use a systems biology approach to obtain better understanding of information processing in the TGFβ signaling pathway. Identifying emerging systems-level properties that arise from network components could help discovering novel therapeutic…

Schlagworte

Biology Work Actinomycin D Actinomycin After Tumor Pneumologie