CareLit Fachartikel
Airway mucins – suitable biomarkers to predict an upcoming exacerbation in COPD and asthma?
T Krause, K Ramaker, N Röckendorf, H Sinnecker, A Frey · Pneumologie · 2016 · Heft 07
Dokument
1115896
CareLit-ID
Jahr
2016
Publikation
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Metadaten
DOI
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Zusammenfassung
Mucins are large glycoproteins lining and protecting the epithelial airway surface. However, their amount, composition and glycosylation pattern can be affected by the airway environment including the inflammatory status of the lung. In COPD amount and ratio of the two most important airway mucins MUC5AC and MUC5B are altered compared to the healthy situation. Moreover, variations in the glycosylation pattern of airway mucins were observed in asthma animal models as well as in patients with cystic fibrosis, making mucin composition and characteristics potential biomarkers to detect and even predict upcoming, lif…
Schlagworte
Antibodies
Asthma
Biomarkers
Bronchoalveolar Lavage Fluid
Bronchoalveolar Lavage
Pneumologie
