CareLit Fachartikel
Identification and characterisation of a novel juvenile onset diabetes (JOD) gene using human pluripotent stem cells
A Illing, I Costa, A Lechel, Q Lin, T Seufferlein, A Kleger · Zeitschrift für Gastroenterologie · 2016 · Heft 08
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1115930
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Jahr
2016
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ja
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Zusammenfassung
Diabetes represents one of the major burdens in the 21st century with approx. 350 million people affected worldwide. Monogenic diabetes such as juvenile onset insulin-dependent diabetes (JOD) or maturity onset diabetes of the young (MODY) accounts for approximately 1 – 2% of diabetes cases and results from mutations that primarily reduce β-cell function. The identification of the genetic basis of these diabetes forms has translated into novel avenues of personalized medicine in the diabetes field, but only few of these genes have been identified to date. Based on published data, we hypothesize that a proportion…
Schlagworte
Diabetes
Novel
Onset
Human
Cells
Mutations
Juvenile
These
Binding
Identification
Using
Monogenic
Zeitschrift für Gastroenterologie
