CareLit Fachartikel
Disease progression in murine systemic lupus erythematosus induced by consumption of amylase trypsin inhibitor (ATIs)
V Zevallos, J Weinmann-Menke, M Meineck, D Schuppan · Zeitschrift für Gastroenterologie · 2016 · Heft 08
Dokument
1115936
CareLit-ID
Jahr
2016
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Zusammenfassung
Background and aims: Wheat alpha-amylase/trypsin inhibitors (ATIs) are activators of the innate immune system via the toll like receptor 4 (TLR4)-MD2-CD14 complex in cells of the mononuclear phagocyte system, triggering several autoimmune/inflammatory diseases. MRL-Faslpr mice, develops progressive and expontaneous glomerular, tubulointerstitial, perivascular kidney disease, arthritis, lymphadenopathy, splenomegaly and circulating autoantibodies that resembles systemic lupus erythematosus (SLE). We explored the effects of dietary ATIs in the development of progressive SLE using the MRL-Fas(lpr) mouse model. Meth…
Schlagworte
Diet
Autoantibodies
Alpha-Amylase
Arthritis
Chemokine
Cytokines
Cytokine
Zeitschrift für Gastroenterologie
