Chronic rejection in orthotopic mouse lung Transplantation models – an experimental reappraisal

Hintergrund: Chronic rejection (CR) remains to be the most important barrier to long term survival in lung transplanted (Tx) patients. The invention of the orthotopic mouse model of lung Tx allowed for the study of new therapeutic strategies against CR as this model physiologically equals the human Tx situation. Several CR models have been proposed, but there is groß heterogeneity with regard to consistency and reproducibility. The aim was therefore to objectively reevaluate current models available. Material und Methode: Three different Tx combinations were employed: minor histocompatibility antigen-mismatched…