Prostate-Specific Membrane Antigen (PSMA) expression in breast cancer and its metastases
M Kasoha, EF Solomayer, C Unger, RM Bohle, C Zaharia, S Ezziddin, I Juhasz-Böss · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein with folate hydrolase and neurocarboxypeptidase activity. PSMA has been shown to be consistently expressed in prostatic carcinoma as well as benign prostatic tissue. In addition, PSMA is selectively expressed in the neovasculator of multiple non-prostatic solid tumours including breast cancers. Inducible PSMA specific expression on angiogenic vasculator suggests that PSMA participates in neovessel growth in developing tumours. Treatment of solid tumours with anti-angiogenic agents has become an established paradigm in c…
