Expression of cyclooxygenase-2 in cervical cancer correlates with lymphangiosis carcinomatosa
F Hoellen, A Waldmann, C Banz-Jansen, A Rody, M Heide, F Köster, J Ribbat-Idel, C Thorns, M Gebhard, M Oberländer, JK Habermann, M Thill · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. We analysed the impact of COX-2 expression in squamous invasive cervical cancer patients. Patients and methods: Tissue samples of 123 cervical cancer patients were collected for a retrospective study performing immunohistochemistry (IHC) with an antibody against COX-2. Patients'clinical and survival data were analysed. Results: Staining for COX-2 was found in 28 patients (23%) with significantly higher percentages in tumor cells compared to peritumoral stroma cells (p < 0.001). COX-2 expression was significantly associa…
