The influence of follicular T helper cells to the adaption of B cells during pregnancy
C Weinhold, DO Muzzio, K Packhäuser, D Krüger, J Ehrhardt, O Heidecke, A Tüngler, M Zygmunt · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: Recently, it has been discovered that B cells display several adaptations in terms of maturation and function during pregnancy. Several factors might account for this, including the action of cytokines like IL-21 and cell-cell interactions from Follicular T helper Cells (TfH). Although the TfH-IL-21-B-Cells pathway has been previously studied in autoimmune diseases, its role in influencing pregnancy outcome has so far not been examined. Our aim is to deeply characterize the role of TfH-cells in normal and altered pregnancies. Materials: We used an established mouse model for pregnancy disturbances.…
