Multimodal immunotherapy for DIPG: status today

Diffuse Intrinsic Pontine Glioma (DIPG) is a brain stem glioma typically found in children aged between 3 and 9. The standard of care is radiotherapy. Clinicians are searching to add (eventually biology-driven) chemotherapy in order to improve the uniformly dismal prognosis. Nevertheless, almost all children die within 2 years after diagnosis. DIPG tumor cells have been shown to be sensitive to Newcastle disease virus (NDV). Culturing DIPG cell lines in the presence of NDV showed reduced viability. A shift in survival curve has been demonstrated in nude mice orthotopically injected with E98 cells and subsequentl…