Carcinogenesis Following Urinary Diversion
T. Kälble, H. Riedmiller · Aktuelle Urologie · 1996 · Heft S 1 · S. 65-68
Bibliografische Angaben
Zusammenfassung
Summary: Clinical data indicate a similar cancer risk in all continent froms of urinary diversion. The comparison of 40 vesicosigmoidostomy vs rats with and 40 (vs) rats without proximal colostomy with a similar tumor incidence of 10/40 (25 %) vs 13/40 (32.5 %) support this theory at least for colonic urinary diversions. N-Nitrosamine excretion in patients with urinary diversions led to the theory of endogenous nitrosamine formation being responsible for intestinal tumors in these patients. The ingestion of high dosages of nitrate (20-100 mg) and the amines proline (Pro/100 mg) and piperazine (Pz/60 mg) as well…