CareLit Fachartikel

Molecular Mechanism of the Alpha-1 Adrenoceptor Induced Cavernous Smooth Muscle Contraction

R. E. Eckert, H. Derouet, J. Utz, W. Trautwein, M. Ziegler · Aktuelle Urologie · 1996 · Heft S 1 · S. 100-103

Dokument
1128884
CareLit-ID
Jahr
1996
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Urologie
Autor:innen
R. E. Eckert, H. Derouet, J. Utz, W. Trautwein, M. Ziegler
Ausgabe
Heft S 1 / 1996
Jahrgang 27
Seiten
100-103
Erschienen: 1996-04-01 00:00:00
ISSN
0001-7868
DOI
10.1055/s-2008-1055668

Zusammenfassung

Summary: The relaxation of cavernous smooth muscle tissue is the essential step in the initiation of penile erection which is the therapeutical goal in the treatment of erectile dysfunction (ED) [10]. Cellular contractility is determined by changes of the free intracellular Ca2+-concentration [Ca2+]i which is modulated by interactions of Ca2+-influx through voltage-dependent Ca2+-channels (ICa), Ca2+-release from intracellular, non-mitochondrial Ca2+-stores and Ca2+-extrusion systems [9, 17]. Hormones, neurotransmitter and other mediators may affect cavernous smooth muscle contractility by modulating these cellu…

Schlagworte

Erectile dysfunction Cavernous smooth muscle [Ca2+]i Fura II Patch-clamp technique Calmodulin Affect Aktuelle Urologie