Clinical benefit and cost-effectiveness of antiviral therapy in treatment-naive patients with chronic hepatitis C. A german health technology assessment commissioned by the German…

Objective: The purpose of this health technology assessment (HTA) commissioned by the German Agency for HTA at the German Federal Ministry of Health was to systematically review the evidence on effectiveness and cost-effectiveness of initial antiviral treatment (AVT) for chronic hepatitis C (CHC) and apply these data in the context of the German health care system. Methods: A systematic literature search was conducted to identify randomised controlled trials (RCTs), meta-analyses, and HTAs that evaluated initial AVT for CHC. The German Hepatitis C Model (GEHMO) – a decision-analytic Markov model – was used to de…