Cervical light-induced fluorescence in pregnant women with cervical insufficiency

Background: The pathophysiology of cervical insufficiency is still poorly understood and we do not have a proper diagnostic tool or even criteria for diagnosis. The human uterine cervix is dominated by fibrous connective tissue and composed of extracellular matrix consisting predominantly of collagen. Women with insufficient cervix may have less collagen content. Measuring the collagen content of the cervical tissue may have use for the diagnosis and planning of any treatment of cervical insufficiency. Objective: The purpose of this study was to investigate cervical light-induced fluorescence (LIF), an index of…