CareLit Fachartikel

The guanine exchange factor Net1 is induced upon TGF-beta stimulation during transdifferentiation of hepatic stellate cells

R Müller, M Kreuzaler, HM Said, AM Gressner, S Dooley · Zeitschrift für Gastroenterologie · 2004 · Heft 02

Dokument
1131263
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Müller, M Kreuzaler, HM Said, AM Gressner, S Dooley
Ausgabe
Heft 02 / 2004
Seiten
–
Erschienen: 2004-02-02 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-816058

Zusammenfassung

Activation of hepatic stellate cells (HSC), the key fibrogenic cell type inside the liver, is mediated by TGF-beta. One hallmark of TGF-beta mediated transdifferentiation is the reorganization of the actin cytoskeleton. Actin reorganization requires activity of RhoA GTPase, which is activated by a Smad-dependent mechanism after stimulation with TGF-beta. Moreover RhoA activity may be related to the amount of Net1 protein, a specific guanine exchange factor for RhoA. We are interested in antifibrotic strategies, ideally by suppressing only the fibrotic action of TGF-beta, without compromising normal defence, tumo…

Schlagworte

Net1 Smad7 TGF-beta fibrosis hepatic stellate cell Actin After Tumor Zeitschrift für Gastroenterologie